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Although the mature formed elements of blood are quite different from each other in both structure and function, all of these cells develop from a common hematopoietic stem cell population, which resides in the bone marrow. The developmental process is called hematopoiesis and represents an enormous metabolic task for the body.

More than billion cells are produced every day. This makes the bone marrow one of the most active organs in the body.

Erythrocytes : physiology and pathophysiology - Semantic Scholar

In adults, most of the active marrow resides in the vertebrae, sternum, and ribs. In children, the marrow is more active in the long bones.

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The process of differentiation from stem cell to mature erythrocyte, granulocyte, lymphocyte, monocyte, or platelet is shown in Figure 6—1. It is not clear exactly what early events lead dividing stem cells down a particular path of development, but many different peptides, called cytokines, are clearly involved Table 6—1 ; see also Chapter 3.

Perhaps because mature white blood cells have a much shorter half-life in the circulation, white blood cell precursors usually outnumber red blood cell precursors by a ratio of in the bone marrow. Hematopoiesis: development of the formed elements of blood from bone marrow stem cells. Cells below the horizontal line are found in normal peripheral blood. The principal cytokines that stimulate each cell lineage to differentiate are shown. See Table 6—1 for details. Redrawn, with permission, from Ganong WF. Review of Medical Physiology, 22nd ed.


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